Effects of tranilast on the epithelial-to-mesenchymal transition in peritoneal mesothelial cells
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چکیده
منابع مشابه
Effects of epithelial-to-mesenchymal transition on acute stress response in human peritoneal mesothelial cells.
BACKGROUND During peritoneal dialysis, mesothelial cells undergo epithelial-to-mesenchymal transition (EMT), resulting in markedly altered protein expression. This potentially includes heat-shock proteins (HSP), the main effectors of cellular repair. Thus, chronic cellular processes, such as EMT, may influence acute stress responses and thus survival of mesothelial cells following non-lethal in...
متن کاملmiRNA589 Regulates Epithelial-Mesenchymal Transition in Human Peritoneal Mesothelial Cells
Background. microRNA (miRNA, miR) are thought to interact with multiple mRNAs which are involved in the EMT process. But the role of miRNAs in peritoneal fibrosis has remained unknown. Objective. To determine if miRNA589 regulates the EMT induced by TGFβ1 in human peritoneal mesothelial cell line (HMrSV5 cells). Methods. 1. Level of miR589 was detected in both human peritoneal mesothelial cells...
متن کاملEffect of aldosterone on epithelial-to-mesenchymal transition of human peritoneal mesothelial cells
BACKGROUND Peritoneal fibrosis is one of the major causes of technical failure in patients on peritoneal dialysis. Epithelial-to-mesenchymal transition (EMT) of the peritoneum is an early and reversible mechanism of peritoneal fibrosis. Human peritoneal mesothelial cells (HPMCs) have their own renin-angiotensin-aldosterone system (RAAS), however, it has not been investigated whether aldosterone...
متن کاملShorter daily dwelling time in peritoneal dialysis attenuates the epithelial-to-mesenchymal transition of mesothelial cells
BACKGROUND Peritoneal dialysis (PD) therapy is known to induce morphological and functional changes in the peritoneal membrane. Long-term exposure to conventional bio-incompatible dialysate and peritonitis is the main etiology of inflammation. Consequently, the peritoneal membrane undergoes structural changes, including angiogenesis, fibrosis, and hyalinizing vasculopathy, which ultimately resu...
متن کاملThe Effect of Statin on Epithelial-Mesenchymal Transition in Peritoneal Mesothelial Cells
BACKGROUND Statins have recently been highlighted for their pleiotropic actions distinct from cholesterol-lowering effects. Despite this interest, it is currently unknown whether statin therapy inhibits peritoneal dialysis (PD)-related epithelial-mesenchymal transition (EMT). METHODS In vitro, human peritoneal mesothelial cells (HPMCs) were exposed to 5.6 mM glucose (NG) or 100 mM glucose (HG...
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ژورنال
عنوان ژورنال: Kidney Research and Clinical Practice
سال: 2019
ISSN: 2211-9140
DOI: 10.23876/j.krcp.19.049